Male Factor Infertility
Male infertility accounts for 30-40% of infertility. Male infertility is usually related to abnormal sperm production or sperm function. Problems can occur anywhere in the production of sperm including hormonal regulation, storage, and transport of sperm. Genetic abnormalities can also contribute to decreased sperm or abnormal function. Fortunately, there are treatments that can help improve a couple’s chances of becoming pregnant even when the semen analysis is abnormal. Intracytoplasmic Sperm Injection (ICSI) is one of the most commonly performed procedures for male infertility. Other procedures including aspirations, biopsies, and varicocele repair can also be useful. Intrauterine insemination, or artificial insemination, can be used in cases of mild male factor infertility. Once you have a diagnosis of male factor infertility, let California IVF help you in selecting the best options available.
Dr. John Gould – Board Certified Urologist
Male fertility specialist, Dr. John Gould, is available to assist men with male factor infertility. Dr. Gould has been providing his specialized services for several Northern California area fertility centers for many years. Through a collaborative agreement with UC Davis, California IVF patients will be able to work more closely with Dr. Gould to provide assistance to couples affected by male factor infertility while utilizing their insurance benefits in some cases. Dr. Gould’s services include the evaluation and treatment of male infertility, vasectomy reversals, surgical extraction of sperm (MESA), and other medical and surgical procedures as needed. Dr. Gould will be available to see patients at UC Davis, and our Sacramento office. For additional information, please do not hesitate to contact our office.
Usually, the first step in evaluating for male infertility is a semen analysis. This is an analysis for the assessment of morphology (shape of sperm), sperm count, motility, and total motile sperm (number of moving sperm in a sample). Two samples may be required to establish the diagnosis of male infertility. An abnormal semen analysis will usually prompt further investigation. Additional tests may include hormonal evaluation, testicular examination, and in some instances, a chromosome analysis. Types of hormone problems that can lead to male infertility include, but are not limited to, high prolactin levels, abnormal testosterone levels, or absent FSH/LH (the hormones that regulate sperm production. An examination for physical abnormalities can be conducted by a urologist.
Normal parameters for a semen analysis:
- Volume > 2 milliliters
- Liquefaction complete by 60 min
- Total Sperm Count > 20 million
- Motility > 50% motile
- Total Motile Concentration (TMC) >20 million per mL
- Morphology (Kruger) > or = to 6% normal shape
Total motile sperm count is the amount of moving sperm in the entire sample. This value is also used as an indicator of the overall assessment of the semen. Generally, total motile counts above 20 million are not associated with significant problems with fertilization as long as the other parameters are not significantly low. Morphology must be conducted by an experienced andrologist, or specialist in sperm evaluation and processing. A properly conducted Kruger Morphology can be very predictive of fertilization potential. Many couples will still consider ICSI in the setting of a borderline semen analysis. Fertilization is the biggest concern with borderline counts. The lower the semen analysis parameters, the higher likelihood of encountering fertilization failure. Fertilization failure is the situation where there are fewer than expected fertilized eggs. This is often avoided by performing ICSI. ICSI is a process involving the injecting a single sperm into an egg. Fertilization rates are often higher with ICSI so women with low numbers of eggs may also elect to do ICSI to maximize the number of fertilized eggs. There is some limited support for performing ICSI in the setting of endometriosis.
Sperm production is regulated by hormones called gonadotropins. These hormones include follicle stimulating hormone (FSH) and luteinizing hormone (LH). FSH is mostly responsible for sperm production, whereas LH is mostly responsible for testosterone production. These hormones can be evaluated for abnormalities which cause inadequate sperm production. Excessive testosterone or other androgens such as DHEA can cause a reduction in sperm production by decreasing circulating levels of FSH and LH. Men should avoid supplements containing unknown substances, especially androgen containing supplements. In addition to supplements, hormonal imbalances may result from effects of other hormones with the body. Prolactinomas (pituitary tumors that secrete prolactin) and thyroid abnormalities can also lead to abnormalities in sperm production. Transient events such as illness and infections may also alter the hormonal regulation of sperm. These effects are usually temporary and resolve with time.
Hormones stimulate the production of sperm within the testicle. As the sperm matures, they are moved towards collecting tubules which allow passage of the mature sperm to the storage area known as the epididymis. The sperm remain there until they are broken down or ejaculated. Ejaculated sperm traverses a tube known as the vas deferens. The vas deferens passes through the prostate gland where the sperm is mixed with additional fluid from the seminal vesicle. The sperm then enters the urethra and out the opening of the penis. Obstructions or anatomical abnormalities along this pathway can lead to male infertility.
Physical abnormalities that can lead to male infertility include problems with the testicles, vas deferens, and prostate. Testicular death (atrophy) or chryptorchidism (non-descended testicle) can happen spontaneously or be associated with chromosomal abnormalities. Excessive dilation of the blood supply around the testicle known as a varicocele can lead to excessive heating of the testicle and cause problems with the sperm. In men with congenital absence of the vas deferens (CAVD), the tube carrying sperm to the penis is absent. This condition has a high association with cystic fibrosis. The tubes and other anatomy of the male reproductive tract may also be blocked due to scar tissue from infections or previous surgery. Prostatitis, an infection of the prostate gland, can lead to high white blood cell counts and an altered acidity (pH) of the semen. This can have an effect on sperm function and survival. Less commonly, the testis do not produce any sperm due to cellular abnormalities of the testicle. If the anatomical problems are not correctable, some couples may need to use donor sperm or consider an aspiration procedure.
When physical barriers to sperm production exist, there are specific procedures that can help. Below is a brief sample of some of the procedures performed for male infertility:
- Vasectomy reversal – for men using a vasectomy for birth control, their vas deferens has been interrupted to prevent the passage of sperm. A vasectomy reversal can restore the opening in some cases. Sperm may also be retrieved by testicular aspiration and combined with ICSI. Antisperm antibodies can often be a problem. It is not uncommon to see declining sperm counts over time with a vasectomy reversal. Despite this, many couples are able to achieve pregnancy through a vasectomy reversal. For more information on vasectomy reversals, antisperm antibodies, and sperm extraction procedures, click here.
- Varicocele ligation – when excessive dilation of the blood vessels around the testicles occurs, excessive heat builds up. The vessels, or varicocele, can be ligated and allow the testis to return to normal temperatures. Often there is an appreciable increase in sperm parameters yet there is still some debate about varicocele ligation improving pregnancy rates. ICSI can frequently overcome the problems with sperm parameters caused by having a varicocele. In most men, varicocele ligations are no longer recommended.
- Testicular biopsy – this is a procedure where a portion of testicular tissue is collected. This can serve as a diagnostic tool in the setting that testicular tissue is abnormal. It can also be one of the last remaining sources of sperm for some men. There is a higher likelihood of immature sperm and the sperm retrieved will likely be in low numbers. ICSI is essential following most biopsy and aspiration procedures. Testicular tissue and sperm are usually collected and frozen prior to IVF procedures.
- Testicular Sperm Extraction (TESE) – this term is applied to the procedure involving sperm aspiration or retrieval from the testicle. Essentially this is a testicular biopsy performed for treatment purposes as opposed to diagnostic purposes.
- Microsurgical Sperm Aspiration (MESA) or Percutaneous Epididymal Sperm Aspiration (PESA) are procedures where sperm is retrieved from the epididymis. Epididymal sperm usually contains more mature sperm . Click here for more information.
The correct procedure and options will be discussed with you prior to proceeding with any treatment. The procedures can usually be performed right in our office with the assistance of a urologist and anesthesiologist. Sperm aspiration techniques and surgical correction of anatomical problems has given many couples hope. Donor sperm represents an alternative to these surgical procedures. Couples should make an informed decision about the options that are right for them. We are happy to answer any questions.
Intracytoplasmic sperm injection (ICSI) is a procedure used when sperm counts or other parameters are below the normal threshold. A single sperm is isolated under the microscope and loaded into a microscopic needle. The sperm is then injected directly into an egg. Ideally there are enough sperm to fertilize all of the oocytes. Motile, forward moving, and normal appearing sperm are preferred in the process of choosing a sperm.
California IVF Fertility Center is fortunate to work with Dr. Gould, a specialist in male infertility and urology. Dr. Ted Tollner is our laboratory director and has his PhD in cell biology with an emphasis in sperm physiology. Charlene Tollner is our expert andrologist with many years of sperm preparation and evaluation. Our patients have the most capable team on their side when faced with male infertility. The team has worked with some of the most difficult cases and achieved success in some of the very rare forms of male infertility such as globozoospermia. Most cases are not as difficult to treat and we can advise you on the available treatment options.
Let us help you!